Cell culturing experiments are ubiquitous to the research of biology, growth of recent medical therapies, and the biomanufacturing trade. Nonetheless, there are nonetheless main technological boundaries limiting the development of data and ballooning the experimental prices related to these techniques. For instance, presently, it’s troublesome to carry out nondisruptive monitoring and management of the cells within the cultured samples. This usually necessitates using sacrificial assays and leads to product inconsistency. To resolve these bottlenecks, we current a prototype “addressable” microfluidic expertise able to spatiotemporal fluid and cell manipulations inside dwelling cultures.
As a proof-of-concept, we show its potential to carry out additive manufacturing by seeding cells in spatial patterns (together with co-culturing a number of cell sorts) and subtractive manufacturing by eradicating floor adherent cells through the targeted circulate of trypsin. Moreover, we present that the gadget can pattern fluids and carry out cell “biopsies” (which might be subsequently despatched for ex situ evaluation), from any location inside its tradition chamber. Lastly, the on-chip plumbing is totally automated utilizing exterior electronics. This opens the potential for performing long-term computer-driven experiments, the place the cell habits is modulated in response to the minimally disruptive observations (e.g., fluid sampling and cell biopsies) all through your complete period of the cultures. A limitation of the offered α prototype is that it is just two-dimensional (2D).
Nonetheless, expertise serves as a basis for finally extending the idea to three-dimensional (3D). One other limitation of the gadget is that it’s presently created from poly(dimethylsiloxane) (PDMS), whereas extra work must be achieved to fabricate from a fabric that degrades away or enable the cells to put down the tissue matrix. Sadly, the present biodegradable supplies are usually not robust sufficient for the fabrication of microfluidic valves. Therefore, new ones should be developed earlier than this expertise can turn out to be mainstream. But, it’s the hope of the authors that this will likely be achieved quickly, and the microfluidic plumbing expertise will finally be scaled as much as 3D, to beat the restrictions of the standard cell culturing platforms.
“Candidatus Mesenet longicola”: Novel Endosymbionts of Brontispa longissima that Induce Cytoplasmic Incompatibility
Intracellular micro organism which might be primarily transmitted maternally have an effect on their arthropod hosts’ biology in numerous methods. One such impact is called cytoplasmic incompatibility (CI), and three bacterial species are recognized to induce CI: Wolbachia, Cardinium hertigii, and a lately discovered alphaproteobacterial symbiont. To make clear the taxonomic standing and supply the basis for future research to disclose CI mechanisms and different phenotypes, we investigated genetic and morphological properties of the third CI inducer that we’ve beforehand reported inducing CI within the coconut beetle Brontispa longissima.
The draft genome of the micro organism was obtained from the oocytes of two isofemale strains of B. longissima contaminated with the micro organism: one from Japan (GL2) and the opposite from Vietnam (L5). Genome options of the symbionts (sGL2 and sL5) had been extremely comparable, exhibiting 1.three Mb in dimension, 32.1% GC content material, and 99.83% common nucleotide sequence. A phylogenetic research based mostly on 43 common and single-copy phylogenetic marker genes signifies that they fashioned a definite clade within the household Anaplasmataceae. 16S rRNA gene sequences point out that they’re completely different from the closest recognized kin, a minimum of on the genus stage.
Subsequently, we suggest a brand new genus and species, “Candidatus Mesenet longicola”, for the symbionts of B. longissima. Morphological analyses confirmed that Ca. M. longicola is an intracellular bacterium that’s ellipsoidal to rod-shaped and 0.94 ± 0.26 μm (imply ± SD) in size, and amassed within the anterior a part of the oocyte. Candidates for the Ca. M. longicola genes answerable for CI induction are additionally described.
Identification of genetic loci related to nocturnal enuresis: a genome-wide affiliation research
Nocturnal enuresis (bedwetting) is a typical dysfunction affecting 10-16% of 7-year-old youngsters globally. Nocturnal enuresis is extremely heritable, however its genetic determinants stay unknown. We aimed to determine genetic variants related to nocturnal enuresis and discover its genetic structure and underlying biology.
We did a genome-wide affiliation research (GWAS) of nocturnal enuresis. Nocturnal enuresis circumstances had been recognized in iPSYCH2012, a big Danish population-based case cohort established to analyze psychological problems, on the idea of 10th revision of the Worldwide Statistical Classification of Ailments (ICD-10) diagnoses and redeemed desmopressin prescriptions in Danish registers. The GWAS was achieved in a genetically homogeneous pattern of unrelated people utilizing logistic regression with related covariates. All genome-wide important variants had been analysed for his or her affiliation with nocturnal enuresis in an unbiased Icelandic pattern from deCODE genetics. Standardised polygenic threat scores for attention-deficit hyperactivity dysfunction (ADHD) and autism spectrum dysfunction had been constructed from abstract statistics of enormous GWASs and analysed for affiliation with nocturnal enuresis.
 Acrylamide 1x cryst. extrapure, 99.5% |
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89314 |
Sisco Laboratories |
100 Gms |
EUR 3.42 |
|
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Description: Part A |
) Urea Crystalline (Molecular Biology Grade) |
|
CE167 |
GeneOn |
1 kg |
EUR 49 |
Urea Crystalline (Molecular Biology Grade) |
|
CE168 |
GeneOn |
5 kg |
EUR 197 |
 Casein, for Molecular Biology |
|
MB279-100G |
EWC Diagnostics |
1 unit |
EUR 110.77 |
|
Description: Casein, for Molecular Biology |
Casein, for Molecular Biology |
|
MB279-500G |
EWC Diagnostics |
1 unit |
EUR 387.65 |
|
Description: Casein, for Molecular Biology |
 Sucrose for molecular biology |
|
27580 |
Sisco Laboratories |
500 Gms |
EUR 4.11 |
|
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Description: Part A |
 Urea for molecular biology, 99.5% |
|
21113 |
Sisco Laboratories |
500 Gms |
EUR 6.5 |
|
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Description: Part A |
 Acriflavine Neutral for molecular biology, 98% |
|
42428 |
Sisco Laboratories |
5 Gms |
EUR 3.15 |
|
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Description: Part B |
 Xylene for molecular biology, 99.5% |
|
45122 |
Sisco Laboratories |
250 ml |
EUR 2.81 |
|
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Description: Part A |
 Glycine for molecular biology, 99.5% |
|
64072 |
Sisco Laboratories |
100 Gms |
EUR 1.64 |
|
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Description: Part A |
 Acetone for molecular biology, 99.8% |
|
27498 |
Sisco Laboratories |
500 ml |
EUR 3.76 |
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Description: Part A |
 Methanol for molecular biology, 99.5% |
|
96446 |
Sisco Laboratories |
500 ml |
EUR 6.23 |
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Description: Part A |
 Carbinol for molecular biology, 99.5% |
|
34883 |
Sisco Laboratories |
500 ml |
EUR 6.23 |
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Description: Part A |
 Formamide for molecular biology, 99.5% |
|
30349 |
Sisco Laboratories |
500 ml |
EUR 5.82 |
|
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Description: Part A |
 Imidazole for molecular biology, 99.5% |
|
61510 |
Sisco Laboratories |
25 Gms |
EUR 5.47 |
|
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Description: Part A |
 Chloroform for molecular biology, 99.8% |
|
96764 |
Sisco Laboratories |
100 ml |
EUR 3.08 |
|
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Description: Part A |
 Acriflavine Hydrochloride for molecular biology, 98.5%-105% |
|
35188 |
Sisco Laboratories |
5 Gms |
EUR 4.05 |
|
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Description: Part B |
 Triethylamine for molecular biology, 99.5% |
|
55221 |
Sisco Laboratories |
500 ml |
EUR 4.11 |
|
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Description: Part A |
 Ficoll 400® for molecular biology |
|
45460 |
Sisco Laboratories |
5 Gms |
EUR 15.6 |
|
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Description: Part B |
 Agarose UltraPhor for molecular biology |
|
27813 |
Sisco Laboratories |
10 Gms |
EUR 46.5 |
|
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Description: Part B |
 Boric Acid for molecular biology, 99.5% |
|
22311 |
Sisco Laboratories |
250 Gms |
EUR 4.04 |
|
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Description: Part A |
 2-Mercaptoethanol ?For Molecular Biology |
|
MB041-100ML |
EWC Diagnostics |
1 unit |
EUR 9.02 |
|
Description: 2-Mercaptoethanol ?For Molecular Biology |
2-Mercaptoethanol ?For Molecular Biology |
|
MB041-500ML |
EWC Diagnostics |
1 unit |
EUR 26.47 |
|
Description: 2-Mercaptoethanol ?For Molecular Biology |
 Triton X-100 for molecular biology |
|
64518 |
Sisco Laboratories |
100 ml |
EUR 6.02 |
|
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Description: Part A |
 MOPS Buffer for molecular biology, 99% |
|
66043 |
Sisco Laboratories |
25 Gms |
EUR 10.28 |
|
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Description: Part B |
 ACES Buffer for molecular biology, 99.5% |
|
27907 |
Sisco Laboratories |
5 Gms |
EUR 5.4 |
|
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Description: Part B |
 Vitamin B12 for molecular biology, 97% |
|
77472 |
Sisco Laboratories |
250 Mg |
EUR 5.78 |
|
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Description: Part B |
 Agarose Low EEO for molecular biology |
|
36601 |
Sisco Laboratories |
10 Gms |
EUR 5.1 |
|
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Description: Part B |
 10X MOPS Buffer for molecular biology |
|
68078 |
Sisco Laboratories |
100 ml |
EUR 4.5 |
|
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Description: Part B |
 CHAPS Buffer for molecular biology, 99.5% |
|
21420 |
Sisco Laboratories |
1 Gms |
EUR 10.73 |
|
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Description: Part B |
 HEPES Buffer for molecular biology, 99.5% |
|
16826 |
Sisco Laboratories |
25 Gms |
EUR 6.3 |
|
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Description: Part B |
 Sodium Azide for molecular biology, 99% |
|
17782 |
Sisco Laboratories |
100 Gms |
EUR 5.47 |
|
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Description: Part A |
 PIPES Buffer for molecular biology, 99% |
|
49159 |
Sisco Laboratories |
100 Gms |
EUR 26.03 |
|
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Description: Part B |
 Agarose High EEO for molecular biology |
|
60645 |
Sisco Laboratories |
25 Gms |
EUR 13.8 |
|
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Description: Part B |
 Jasmonic Acid for molecular biology, 95% |
|
79238 |
Sisco Laboratories |
25 Mg |
EUR 120.9 |
|
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Description: Part B |
 Protamine Sulfate for molecular biology, 90-110% |
|
78349 |
Sisco Laboratories |
1 Gms |
EUR 22.5 |
|
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Description: Part B |
 Oil Red O for molecular biology, 75% |
|
23576 |
Sisco Laboratories |
25 Gms |
EUR 5.33 |
|
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Description: Part B |
 Sodium Chloride for molecular biology, 99.9% |
|
33205 |
Sisco Laboratories |
500 Gms |
EUR 4.52 |
|
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Description: Part A |
 Agarose Medium EEO for molecular biology |
|
10423 |
Sisco Laboratories |
10 Gms |
EUR 6.75 |
|
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Description: Part B |
 for molecular biology, 99.8%) Isopropanol (IPA) for molecular biology, 99.8% |
|
38445 |
Sisco Laboratories |
100 ml |
EUR 1.71 |
|
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Description: Part A |
 for molecular biology, 99.9%) Acetonitrile (ACN) for molecular biology, 99.9% |
|
62006 |
Sisco Laboratories |
250 ml |
EUR 4.93 |
|
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Description: Part A |
 Ethidium Bromide for molecular biology, 95% |
|
93079 |
Sisco Laboratories |
1 Gms |
EUR 4.58 |
|
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Description: Part A |
 Ammonium Acetate for molecular biology, 98% |
|
37829 |
Sisco Laboratories |
100 Gms |
EUR 2.12 |
|
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Description: Part A |
 Agarose Low Melting for molecular biology |
|
32417 |
Sisco Laboratories |
5 Gms |
EUR 22.5 |
|
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Description: Part B |
 Potassium Acetate for molecular biology, 99.5% |
|
96248 |
Sisco Laboratories |
100 Gms |
EUR 2.74 |
|
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Description: Part A |
 Ammonium Chloride for molecular biology, 99.5% |
|
16992 |
Sisco Laboratories |
500 Gms |
EUR 4.52 |
|
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Description: Part A |
 Ammonium Sulphate for molecular biology, 99.5% |
|
82126 |
Sisco Laboratories |
250 Gms |
EUR 4.93 |
|
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Description: Part A |
 Potassium Chloride for molecular biology, 99.5% |
|
84984 |
Sisco Laboratories |
500 Gms |
EUR 6.16 |
|
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Description: Part A |
 Sodium Bicarbonate for molecular biology, 99.7% |
|
36328 |
Sisco Laboratories |
500 Gms |
EUR 5.47 |
|
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Description: Part A |
 for molecular biology, 99.5%) Glycerol (Glycerine) for molecular biology, 99.5% |
|
62417 |
Sisco Laboratories |
100 ml |
EUR 2.05 |
|
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Description: Part A |
 2-Mercaptoethanol for molecular biology, 99% |
|
83759 |
Sisco Laboratories |
100 ml |
EUR 5.27 |
|
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Description: Part A |
 for molecular biology, 99.9%) Dichloromethane (DCM) for molecular biology, 99.9% |
|
41512 |
Sisco Laboratories |
250 ml |
EUR 3.22 |
|
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Description: Part A |
 for molecular biology, 99.8%) Tetrahydrofuran (THF) for molecular biology, 99.8% |
|
92562 |
Sisco Laboratories |
250 ml |
EUR 3.28 |
|
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Description: Part A |
 for molecular biology, 99%) Dithioerythritol (DTE) for molecular biology, 99% |
|
53384 |
Sisco Laboratories |
1 Gms |
EUR 9.53 |
|
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Description: Part B |
 for molecular biology, 98%) meta-Topolin (mT) for molecular biology, 98% |
|
68913 |
Sisco Laboratories |
25 Mg |
EUR 17.48 |
|
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Description: Part B |
 L-Ascorbic Acid for molecular biology, 99.7% |
|
14116 |
Sisco Laboratories |
25 Gms |
EUR 1.64 |
|
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Description: Part A |
 HEPES Sodium Salt for molecular biology, 99% |
|
32225 |
Sisco Laboratories |
25 Gms |
EUR 11.85 |
|
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Description: Part B |
 Glycogen ex. Oyster for molecular biology, 85% |
|
49740 |
Sisco Laboratories |
1 Gms |
EUR 7.5 |
|
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Description: Part B |
 D-Sorbitol Powder for molecular biology, 98% |
|
99103 |
Sisco Laboratories |
500 Gms |
EUR 10.33 |
|
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Description: Part A |
 Acetic Acid Glacial for molecular biology, 99.9% |
|
59788 |
Sisco Laboratories |
100 ml |
EUR 3.56 |
|
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Description: Part A |
 Brilliant Blue G-250 for molecular biology |
|
64222 |
Sisco Laboratories |
5 Gms |
EUR 4.65 |
|
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Description: Part B |
 Brilliant Blue R-250 for molecular biology |
|
93473 |
Sisco Laboratories |
5 Gms |
EUR 4.35 |
|
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Description: Part B |
 for molecular biology, 95%) Propidium Iodide (PI) for molecular biology, 95% |
|
11195 |
Sisco Laboratories |
10 Mg |
EUR 17.63 |
|
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Description: Part B |
 for molecular biology) Polysorbate 20 (Tween 20) for molecular biology |
|
65296 |
Sisco Laboratories |
100 Gms |
EUR 10.81 |
|
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|
Description: Part A |
 Tris Buffer Superior for molecular biology, 99.9% |
|
37969 |
Sisco Laboratories |
100 Gms |
EUR 7.59 |
|
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|
Description: Part A |
 Molecular Biology Grade Water for RT-PCR |
|
ML065-1.5ML |
EWC Diagnostics |
1 unit |
EUR 7.82 |
|
Description: Molecular Biology Grade Water for RT-PCR |
 10X TE Buffer pH-8.0 for molecular biology |
|
51782 |
Sisco Laboratories |
100 ml |
EUR 9.45 |
|
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Description: Part B |
 10X TBE Buffer pH-8.3 for molecular biology |
|
83170 |
Sisco Laboratories |
200 ml |
EUR 4.95 |
|
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|
Description: Part B |
 Tris Buffer AR, ACS for molecular biology, 99.9% |
|
71033 |
Sisco Laboratories |
100 Gms |
EUR 6.02 |
|
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|
Description: Part A |
 10X TAE Buffer pH-8.3 for molecular biology |
|
71989 |
Sisco Laboratories |
100 ml |
EUR 4.43 |
|
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|
Description: Part B |
 MES Monohydrate Buffer for molecular biology, 99% |
|
26854 |
Sisco Laboratories |
25 Gms |
EUR 11.03 |
|
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Description: Part B |
 for molecular biology, 99.5%) Glutathione Reduced (GSH) for molecular biology, 99.5% |
|
11514 |
Sisco Laboratories |
1 Gms |
EUR 5.55 |
|
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Description: Part B |
 for molecular biology, 98%) DL-Dithiothreitol (DTT) for molecular biology, 98% |
|
17315 |
Sisco Laboratories |
1 Gms |
EUR 5.18 |
|
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Description: Part B |
 for molecular biology, 99.9%) Trifluoroacetic Acid (TFA) for molecular biology, 99.9% |
|
40801 |
Sisco Laboratories |
100 ml |
EUR 22.92 |
|
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Description: Part A |
 for molecular biology, 99%) Ammonium Persulphate (APS) for molecular biology, 99% |
|
65553 |
Sisco Laboratories |
25 Gms |
EUR 1.64 |
|
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Description: Part A |
 Sodium Acetate Anhydrous for molecular biology, 99% |
|
22342 |
Sisco Laboratories |
250 Gms |
EUR 3.56 |
|
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|
Description: Part A |
 for molecular biology, 99.8%) Dimethyl Sulphoxide (DMSO) for molecular biology, 99.8% |
|
24075 |
Sisco Laboratories |
100 ml |
EUR 6.02 |
|
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|
Description: Part A |
 Salt for molecular biology) Acridine Orange hemi(Zinc Chloride) Salt for molecular biology |
|
37751 |
Sisco Laboratories |
5 Gms |
EUR 12.38 |
|
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Description: Part B |
 Sodium Acetate Trihydrate for molecular biology, 99.5% |
|
88035 |
Sisco Laboratories |
250 Gms |
EUR 2.33 |
|
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|
Description: Part A |
 Cesium Sulphate extrapure for molecular biology, 99.9% |
|
57455 |
Sisco Laboratories |
10 Gms |
EUR 7.5 |
|
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Description: Part B |
 for molecular biology, 99.5%) Glutathione Oxidized (GSSG) for molecular biology, 99.5% |
|
22151 |
Sisco Laboratories |
250 Mg |
EUR 22.5 |
|
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Description: Part B |
 for molecular biology, 99%) Guanidine Thiocyanate (GTC) for molecular biology, 99% |
|
80272 |
Sisco Laboratories |
100 Gms |
EUR 5.47 |
|
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Description: Part A |
 Cesium Chloride ultrapure for molecular biology, 99.9% |
|
32355 |
Sisco Laboratories |
25 Gms |
EUR 18 |
|
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|
Description: Part B |
 Pyridine, GlenBiol™, suitable for molecular biology with molecular sieve |
|
GS8780 |
Glentham Life Sciences |
2500ml |
EUR 239.63 |
Pyridine, GlenBiol™, suitable for molecular biology with molecular sieve |
|
GS8780-2500 |
Glentham Life Sciences |
2500 |
EUR 249.8 |
|
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 Calcium Chloride Dihydrate for molecular biology, 99.5% |
|
97080 |
Sisco Laboratories |
100 Gms |
EUR 2.12 |
|
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Description: Part A |
 for molecular biology, 99%) Diethyl Pyrocarbonate (DEPC) for molecular biology, 99% |
|
46791 |
Sisco Laboratories |
5 ml |
EUR 9 |
|
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Description: Part B |
 20X SSC Buffer pH 6.9-7.1 for molecular biology |
|
12590 |
Sisco Laboratories |
200 ml |
EUR 2.48 |
|
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|
Description: Part B |
 Bromocresol Purple Sodium Salt for molecular biology |
|
24836 |
Sisco Laboratories |
5 Gms |
EUR 2.05 |
|
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|
Description: Part A |
 for molecular biology, 99.5%) Guanidine Hydrochloride (GHC) for molecular biology, 99.5% |
|
45539 |
Sisco Laboratories |
100 Gms |
EUR 4.79 |
|
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Description: Part A |
 for molecular biology) Polyethylene Glycol 8000 (PEG 8000) for molecular biology |
|
54866 |
Sisco Laboratories |
500 Gms |
EUR 11.97 |
|
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|
Description: Part A |
 for molecular biology) 10X Tris Buffered Saline (TBS) for molecular biology |
|
83471 |
Sisco Laboratories |
500 ml |
EUR 14.7 |
|
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Description: Part B |
 Magnesium Acetate Tetrahydrate for molecular biology, 99% |
|
50488 |
Sisco Laboratories |
100 Gms |
EUR 2.74 |
|
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|
Description: Part A |
 Magnesium Chloride Hexahydrate for molecular biology, 99.5% |
|
91417 |
Sisco Laboratories |
250 Gms |
EUR 4.45 |
|
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|
Description: Part A |
 Magnesium Sulphate Heptahydrate for molecular biology, 99.5% |
|
74440 |
Sisco Laboratories |
500 Gms |
EUR 6.16 |
|
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|
Description: Part A |
 for molecular biology, 99%) Tris Hydrochloride (Tris HCl) for molecular biology, 99% |
|
89781 |
Sisco Laboratories |
100 Gms |
EUR 9.37 |
|
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Description: Part A |
 for molecular biology, 99%) L-Lysine Monohydrate (base) for molecular biology, 99% |
|
45976 |
Sisco Laboratories |
25 Gms |
EUR 37.63 |
|
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Description: Part A |
 Agarose Low EEO Superior Grade for molecular biology |
|
23287 |
Sisco Laboratories |
10 Gms |
EUR 6 |
|
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|
Description: Part B |
) DTT (Molecular Biology Grade) |
|
CE131 |
GeneOn |
5 g |
EUR 44 |
DTT (Molecular Biology Grade) |
|
CE132 |
GeneOn |
10 g |
EUR 88 |
DTT (Molecular Biology Grade) |
|
CE133 |
GeneOn |
25 g |
EUR 170 |
) NAD (Molecular Biology Grade) |
|
CE196 |
GeneOn |
1 g |
EUR 34 |
NAD (Molecular Biology Grade) |
|
CE197 |
GeneOn |
5 g |
EUR 137 |
) NBT (Molecular Biology Grade) |
|
CE209 |
GeneOn |
1 g |
EUR 96 |
NBT (Molecular Biology Grade) |
|
CE210 |
GeneOn |
5 g |
EUR 345 |
 10X Tris-Glycine-SDS Buffer for molecular biology |
|
57806 |
Sisco Laboratories |
200 ml |
EUR 3.6 |
|
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Description: Part B |
 for molecular biology, 99.9%) N,N-Dimethylformamide (DMF) for molecular biology, 99.9% |
|
24017 |
Sisco Laboratories |
100 ml |
EUR 3.08 |
|
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Description: Part A |
 Cesium Chloride extrapure AR for molecular biology, 99.9% |
|
22966 |
Sisco Laboratories |
25 Gms |
EUR 14.63 |
|
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Description: Part B |
 10X Tris-Tricine-SDS Buffer for molecular biology |
|
37852 |
Sisco Laboratories |
500 ml |
EUR 9.08 |
|
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Description: Part B |
 EDTA Disodium Salt Dihydrate for molecular biology, 99.5% |
|
43272 |
Sisco Laboratories |
100 Gms |
EUR 2.26 |
|
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Description: Part A |
 DMSO, Molecular Biology Grade |
|
40470006-1 |
Bio-WORLD |
100 mL |
EUR 108.14 |
|
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DMSO, Molecular Biology Grade |
|
40470006-2 |
Bio-WORLD |
250 mL |
EUR 182.67 |
|
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DMSO, Molecular Biology Grade |
|
40470006-3 |
Bio-WORLD |
500 mL |
EUR 342.49 |
|
|
 EGTA, Molecular Biology Grade |
|
40500028-2 |
Bio-WORLD |
50 g |
EUR 130.53 |
|
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EGTA, Molecular Biology Grade |
|
40500028-3 |
Bio-WORLD |
100 g |
EUR 217.78 |
|
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EGTA, Molecular Biology Grade |
|
40500028-4 |
Bio-WORLD |
500 g |
EUR 734.55 |
|
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EGTA, Molecular Biology Grade |
|
40500028-5 |
Bio-WORLD |
1 kg |
EUR 1119.67 |
|
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EGTA, Molecular Biology Grade |
|
40500028-6 |
Bio-WORLD |
2 kg |
EUR 2070.09 |
|
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) BCIP (Molecular Biology Grade) |
|
CE108 |
GeneOn |
250 mg |
Ask for price |
BCIP (Molecular Biology Grade) |
|
CE109 |
GeneOn |
1 g |
EUR 82 |
) DAPI (Molecular Biology Grade) |
|
CE117 |
GeneOn |
5 mg |
EUR 40 |
Among the many potential nocturnal enuresis threat genes mapped, PRDM13 and EDNRB have organic capabilities related to recognized pathophysiological mechanisms in nocturnal enuresis, and SIM1 regulates the formation of the hypothalamic neuroendocrine lineage that produces arginine vasopressin, a well-known nocturnal enuresis drug goal. This research reveals that widespread genetic variants contribute significantly to nocturnal enuresis, and it identifies potential nocturnal enuresis threat genes with roles in sleep, urine manufacturing, and bladder operate. Provided that accessible therapies goal these mechanisms, any of the recognized genes and their useful gene networks are potential drug targets.
